HCID 67168853、化合物 → Methyl 2-((3S,4S)-4-(aminomethyl)-1-methylpyrrolidin-3-yl)-6-(trifluoromethoxy)benzoate
反応式
[C:1]([C@H:3]1[CH2:7][N:6]([CH3:8])[CH2:5][C@@H:4]1[C:9]1[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]([F:23])([F:22])[F:21])[C:10]=1[C:11]([O:13][CH3:14])=[O:12])#[N:2].C(N1C[C@@H](C#N)[C@H](C2C=CC(Cl)=CC=2C(OC)=O)C1)C1C=CC=CC=1>>[NH2:2][CH2:1][C@H:3]1[CH2:7][N:6]([CH3:8])[CH2:5][C@@H:4]1[C:9]1[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]([F:23])([F:21])[F:22])[C:10]=1[C:11]([O:13][CH3:14])=[O:12]参加物
3
実験手順
The title compound was prepared according to the procedure outlined in Example 45C substituting the product obtained from Example 110A for the product obtained from Example 45B. In this instance, the aminoester did not cyclize. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.42 (s, 1H) 2.10-2.21 (m, 1H) 2.32-2.48 (m, 4H) 2.55-2.63 (m, 1H) 2.73 (t, J=8.48 Hz, 1H) 2.79-2.87 (m, 3H) 3.87 (s, 3H) 7.28-7.36 (m, 1H) 7.55-7.64 (m, 3H); MS (DCI+) m/z 333.2 [M+H]+.
出典と根拠
- ORDレコード
- ord-ae95f29bbc3b40f894d3828d0b594a87
- 出典データセット
- uspto-grants-2014_09