関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Methylpiperazine | HCID 66057 | — |
| 反応物 | 4-Fluorobenzamide | HCID 71572 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | (RS)-4-(3-methylpiperazin-1-yl)benzamide | HCID 19367109 | 87.9% |
反応手順
A mixture of 4-fluorobenzamide (Aldrich; 2.432 g), (RS)-2-methylpiperazine (Aldrich; 4.247 g), and water (9 mL) is heated at 100° C. for 7 days. The mixture is then cooled to 41° C. and water is added. The solid is collected, washed with water and toluene and dried under reduced pressure to give 3.37 g of (RS)-4-(3-methylpiperazin-1-yl)benzamide; 1H NMR (CDCl3, CD3OD) δ 1.17, 2.48, 2.82, 2.94-3.15, 3.04, 3.68, 6.89, 7.73.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06013654 |
|---|
| 出典データセット | uspto-grants-2000_01 |
|---|
| ORD ID | ord-6e947ac27ebe459d931f683fc1d796c6 |
|---|
| 出典メモ | uspto-grants-2000_01 |
|---|
