Ammonia → 7-Amino-5-azaspiro(2.4)heptan-4-one

HRID 849667

反応式

HRID 849667 の反応式
[NH2:1][CH:2]([C:5]1([C:8]([O:10]CC)=O)[CH2:7][CH2:6]1)[C:3]#[N:4].N.[H][H]>[Ni]>[NH2:1][CH:2]1[C:5]2([CH2:7][CH2:6]2)[C:8](=[O:10])[NH:4][CH2:3]1

参加物

5

反応物 3

HCID 222AmmoniaHCID 110192531-(1-Amino-1-cyanomethyl)-1-ethoxycarbonylcyclopropaneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 109314407-Amino-5-azaspiro(2.4)heptan-4-one収率 92.3%

試薬・触媒・溶媒 1

HCID 935Nickel触媒

実験手順

An autoclave was charged with 1.0 g of 1-(1-amino-1-cyanomethyl)-1-ethoxycarbonylcyclopropane, 0.4 ml of Raney nickel and 4.0 ml of ammonia-saturated ethanol, and the contents were stirred at 80° C. for 4 hours in an atmosphere of hydrogen under a pressure of 20 kg/cm2. After completion of the reaction, the catalyst was removed by filtration and the resulting filtrate was concentrated under a reduced pressure to obtain 692 mg (92%) of the title compound in the form of colorless crystals. The thus obtained product was recrystallized from ethyl acetate and diethyl ether and used as a sample for analyses.

後処理

  1. customAfter completion of the reaction
  2. customthe catalyst was removed by filtration
  3. concentrationthe resulting filtrate was concentrated under a reduced pressure

出典と根拠

ORDレコード
ord-eb5240bae3324c36b82a051922935fb4
出典データセット
uspto-grants-2000_01
特許番号
US06013806

関連ノート

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