Ammonia → 2-Phenylbenzo[d]oxazole-4-carboxamide

HRID 850055ノート

反応式

HRID 850055 の反応式
[C:1]1([C:7]2[O:8][C:9]3[C:10](=[C:12]([C:16]([O:18]C)=O)[CH:13]=[CH:14][CH:15]=3)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH3:20].CCOC(C)=O>CO>[C:1]1([C:7]2[O:8][C:9]3[C:10](=[C:12]([C:16]([NH2:20])=[O:18])[CH:13]=[CH:14][CH:15]=3)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 222AmmoniaHCID 8857Ethyl AcetateHCID 10824752Methyl 2-phenylbenzoxazole-4-carboxylate

生成物 1

HCID 117763402-Phenylbenzo[d]oxazole-4-carboxamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
40 °C

実験手順

To a solution of methyl 2-phenylbenzoxazole-4-carboxylate (0.02 g; 0.0905 mmol) in methanol (3 ml) was added aqueous ammonia (3 ml). This was warmed to 40° C. and left to stir, whilst the reaction was monitored by TLC (1:4 EtOAc:petrol). Once all the starting material had reacted a white precipitate was formed. The solvent was removed to yield a white solid, which was recrystallised from ethyl acetate and petrol (70%).

後処理

  1. waitleft
  2. customOnce all the starting material had reacted a white precipitate
  3. customwas formed
  4. customThe solvent was removed
  5. customto yield a white solid, which
  6. customwas recrystallised from ethyl acetate and petrol (70%)

出典と根拠

ORDレコード
ord-420b499dd7dc45a5a41fbd9efe2f27c2
出典データセット
uspto-grants-2000_01
特許番号
US06015827

反応ノート

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