Chloromethyl ethyl ether → 1-Ethoxymethyl-3-methylthio-1,2,4-triazole
反応式
[CH3:1][S:2][C:3]1[NH:7][N:6]=[CH:5][N:4]=1.[CH2:8]([O:10][CH2:11]Cl)[CH3:9]>C1(C)C=CC=CC=1>[CH2:8]([O:10][CH2:11][N:6]1[CH:5]=[N:4][C:3]([S:2][CH3:1])=[N:7]1)[CH3:9]参加物
4
実験手順
A suspension of 5-methylthio-1,2,4-triazole (6.19, 53 mmol) and chloromethyl ethyl ether (2.5 ml, 26 mmol) in toluene (40 ml) was stirred at room temperature for 24 hours. The mixture was filtered and the filtrate was evaporated under reduced pressure. The residue was chromatographed on silica by elution with ethyl acetate/diethylamine (95:5) to yield the title compound (1.1 g, 27%), as a colourless oil, which was characterised by
後処理
- filtrationThe mixture was filtered
- customthe filtrate was evaporated under reduced pressure
- customThe residue was chromatographed on silica by elution with ethyl acetate/diethylamine (95:5)
出典と根拠
- ORDレコード
- ord-89716f5e9a584abf9019026f1c6abb45
- 出典データセット
- uspto-grants-2000_01
- 特許番号
- US06015825
反応ノート
読み込み中…