化工社化工社 化学情報印刷レポート · 研究参考用
5-Indolylboronic acid → US9814704, Example 20
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Indolylboronic acid | HCID 2734361 | — |
| 反応物 | 3,4,5-Trimethoxybenzeneboronic acid | HCID 2734390 | — |
| 反応物 | (2-Aminopyrimidin-5-yl)boronic acid | HCID 17750211 | — |
| 反応物 | 5-bromo-3-iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridine | HCID 49759066 | — |
| 反応物 | 5-bromo-3-(1H-indol-5-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine | HCID 66779176 | — |
| 生成物 | US9814704, Example 20 | HCID 66779903 | — |
反応手順
Compound W was prepared by a method analogous to that described in Example 1 by substituting 2-aminopyrimidin-5-ylboronic acid for 1H-indol-5-ylboronic acid in the reaction with Intermediate A and 2-aminopyrimidin-5-ylboronic acid for 3,4,5-trimethoxyphenylboronic acid in the reaction with Intermediate B. HPLC retention time: 1.17 minutes. MS ESI (m/z): 305.2 (M+H)+, calc. 304.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846909B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-7bb733119f274e7eb823eb22cb7ce4d2 |
| 出典メモ | uspto-grants-2014_09 |