化工社化工社 化学情報印刷レポート · 研究参考用
5-Indolylboronic acid → 4-(5-(4-amino-3-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Indolylboronic acid | HCID 2734361 | — |
| 反応物 | 3,4,5-Trimethoxybenzeneboronic acid | HCID 2734390 | — |
| 反応物 | 5-bromo-3-iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridine | HCID 49759066 | — |
| 反応物 | (4-Amino-3-methoxyphenyl)boronic acid | HCID 57473274 | — |
| 反応物 | 5-bromo-3-(1H-indol-5-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine | HCID 66779176 | — |
| 生成物 | 4-(5-(4-amino-3-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)benzamide | HCID 46234351 | — |
反応手順
Compound AD was prepared by a method analogous to that described in Example 1 by substituting 4-carbamoylphenylboronic acid for 1H-indol-5-ylboronic acid in the reaction with Intermediate A and 4-amino-3-methoxyphenylboronic acid for 3,4,5-trimethoxyphenylboronic acid in the reaction with Intermediate B. HPLC retention time: 1.46 minutes. MS ESI (m/z): 359.2 (M+H)+, calc. 358.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846909B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-8dc9cdbe77ea406da1841f3d77a4c1bd |
| 出典メモ | uspto-grants-2014_09 |