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Quinoline → Ethyl 3-aminopent-4-enoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Quinoline | HCID 7047 | — |
| 反応物 | Ethyl 3-amino-4-pentynoate | HCID 22006121 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Pd barium sulfate | HCID 16218511 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Ethyl 3-aminopent-4-enoate | HCID 10057602 | 185.1% |
反応手順
A mixture of 5% Pd/BaSO4 (0.025 g) and quinoline (0.30 mL) was stirred under a ballon of hydrogen for 30 minutes. 3-Amino-pent-4-ynoic acid ethyl ester 17-1 (1.77 g, 10.0 mmol) in EtOH (15 mL) was added and the solution stirred for an additional 2.5 hours. The solution was filtered through a pad of celite and concentrated in vacuo to provide 2.65 g of crude product 19-1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06017926 |
| 出典データセット | uspto-grants-2000_01 |
| ORD ID | ord-d1d55e3e70e0485588959b6a2941dcb8 |
| 出典メモ | uspto-grants-2000_01 |