Hydrochloric Acid → 9-bromo-2-(3-hydroxypropyloxy)-5-(3-pyridylmethyl)-4H-pyrido[3,2,1-jk]carbazole-4-one hydrochloride

HRID 850811ノート

反応式

HRID 850811 の反応式
[Br:1][C:2]1[CH:14]=[CH:13][C:12]2[C:11]3[C:6]4=[C:7]([C:20](=[O:30])[C:21]([CH2:23][C:24]5[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=5)=[CH:22][N:5]4[C:4]=2[CH:3]=1)[CH:8]=[C:9]([O:15][CH2:16][CH2:17][CH2:18][OH:19])[CH:10]=3.[ClH:31]>CO>[ClH:31].[Br:1][C:2]1[CH:14]=[CH:13][C:12]2[C:11]3[C:6]4=[C:7]([C:20](=[O:30])[C:21]([CH2:23][C:24]5[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=5)=[CH:22][N:5]4[C:4]=2[CH:3]=1)[CH:8]=[C:9]([O:15][CH2:16][CH2:17][CH2:18][OH:19])[CH:10]=3

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 98724899-bromo-2-(3-hydroxypropyloxy)-5-(3-pyridylmethyl)-4H-pyrido [3,2,1-jk]carbazole-4-one

生成物 1

HCID 99357069-bromo-2-(3-hydroxypropyloxy)-5-(3-pyridylmethyl)-4H-pyrido[3,2,1-jk]carbazole-4-one hydrochloride収率 98%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

9-bromo-2-(3-hydroxypropyloxy)-5-(3-pyridylmethyl)-4H-pyrido[3,2,1-jk]carbazole-4-one (300 mg) obtained in Example 110 was suspended in methanol (10 ml) and a solution of hydrogen chloride in methanol (5 ml) was added on an ice bath. The mixture was stirred for 5 minutes. The solvent was evaporated under reduced pressure, and the resulting crude crystals were washed with ether to obtain the title compound (320 mg, 98%).

後処理

  1. customThe solvent was evaporated under reduced pressure
  2. washthe resulting crude crystals were washed with ether

出典と根拠

ORDレコード
ord-f91f3c9e5ebe4250970aa45f4f4b282c
出典データセット
uspto-grants-2000_01
特許番号
US06018046

反応ノート

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