Hydrochloric Acid → 4-Hexadecylamino-2-thiophenecarboxylic acid

HRID 850962ノート

反応式

HRID 850962 の反応式
[C:1]([C:4]1[S:5][CH:6]=[C:7]([NH:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[CH:8]=1)(=[O:3])N.Cl.C[O:28]CCO>>[CH2:10]([NH:9][C:7]1[CH:8]=[C:4]([C:1]([OH:28])=[O:3])[S:5][CH:6]=1)[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 80192-MethoxyethanolHCID 131349932-Carbamyl-4-hexadecylaminothiophene

生成物 1

HCID 131349944-Hexadecylamino-2-thiophenecarboxylic acid

実験手順

A mixture of 4.4 g. of 2-carbamyl-4-hexadecylaminothiophene, 50 ml. of methyl cellosolve, and 50 ml. of 6 N hydrochloric acid is refluxed for 40 hours and then allowed to cool. The solid is filtered and recrystallized from methanol. The solid is then dissolved in hot sodium bicarbonate solution, filtered, and the filtrate is acidified with concentrated hydrochloric acid. The resulting precipitate is collected and recrystallized from isopropanol to yield the product.

後処理

  1. additionA mixture of 4.4 g
  2. temperatureto cool
  3. filtrationThe solid is filtered
  4. customrecrystallized from methanol
  5. dissolutionThe solid is then dissolved in hot sodium bicarbonate solution
  6. filtrationfiltered
  7. customThe resulting precipitate is collected
  8. customrecrystallized from isopropanol
  9. customto yield the product

出典と根拠

ORDレコード
ord-77c3e18d0c7043d184750298c932b43d
出典データセット
uspto-grants-1983_05
特許番号
US04382143

反応ノート

読み込み中…