2-Chlorophenol → HCID 70530998、化合物

HRID 851063ノート

反応式

HRID 851063 の反応式
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][C@@H:9]([OH:12])[C@H:8]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:7]1)=[O:5])[CH3:2].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[Cl:38][C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=1O.N(C(OCC)=O)=NC(OCC)=O>C1C=CC=CC=1>[Cl:38][C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=1[O:12][C@H:9]1[CH2:10][CH2:11][N:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH2:7][C@H:8]1[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

参加物

6

反応物 4

HCID 72452-ChlorophenolHCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 13039299HCID 13039299、化合物

生成物 1

HCID 70530998HCID 70530998、化合物

試薬・触媒・溶媒 1

HCID 241Benzene溶媒2 回

実験手順

To a stirred mixture of 6.23 g of trans-1-ethoxycarbonyl-3-phenyl-4-piperidinol, 7.21 g of triphenylphosphine, 2.85 g of 2-chlorophenol and 250 ml of benzene is added dropwise at 5° C. under nitrogen, a solution of 4.79 g of diethyl azodicarboxylate in 250 ml of benzene. After the addition is complete, the mixture is stirred overnight at room temperature. The reaction mixture is processed according to the procedure of Example 75 to give product as a gum.

後処理

  1. additionis added dropwise at 5° C. under nitrogen
  2. additionAfter the addition
  3. customto give product as a gum

出典と根拠

ORDレコード
ord-a6314fb4593b483d969d0b330d50622c
出典データセット
uspto-grants-1983_05
特許番号
US04382141

反応ノート

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