Potassium Iodide → 1-(2,3-Difluoro-6-nitrophenoxy)propan-2-one

HRID 851079

反応式

HRID 851079 の反応式
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([N+:9]([O-:11])=[O:10])[C:3]=1[OH:12].Cl[CH2:14][C:15](=[O:17])[CH3:16].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CC(C)=O>[CH2:14]([O:12][C:3]1[C:2]([F:1])=[C:7]([F:8])[CH:6]=[CH:5][C:4]=1[N+:9]([O-:11])=[O:10])[C:15]([CH3:16])=[O:17]

参加物

6

反応物 4

HCID 4875Potassium IodideHCID 6571ChloroacetoneHCID 11430Potassium CarbonateHCID 27337452,3-Difluoro-6-nitrophenol

生成物 1

HCID 12682411-(2,3-Difluoro-6-nitrophenoxy)propan-2-one収率 65.3%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

5.8 g of 2,3-difluoro-6-nitrophenol, 5.0 g of monochloroacetone, 8.0 g of potassium carbonate and 0.8 g of potassium iodide were added to 100 ml of acetone and the mixture was refluxed for 4 hours. After the removal of insoluble material by filtration, the solvent was evaporated and the residue was distributed between chloroform and water. The chloroform layer was washed with water and was dried, then the solvent was evaporated. The residue was treated with n-hexane to provide 5.0 g of 2-acetonyloxy-3,4-difluoronitrobenzene as light yellow crystals with m.p. 61° C.

後処理

  1. temperaturethe mixture was refluxed for 4 hours
  2. customAfter the removal of insoluble material
  3. filtrationby filtration
  4. customthe solvent was evaporated
  5. washThe chloroform layer was washed with water
  6. customwas dried
  7. customthe solvent was evaporated
  8. additionThe residue was treated with n-hexane

出典と根拠

ORDレコード
ord-6fb2dfaa0e1c49c2aa2f8266807d0b80
出典データセット
uspto-grants-1983_05
特許番号
US04382892

関連ノート

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