Methylamine → N-[[[2-[[5-(Dimethylaminomethyl)-3-thienylmethyl]thio]ethyl]amino](methylamino)methylene]methanesulphonamide

HRID 851113ノート

反応式

HRID 851113 の反応式
[NH2:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[CH:7]=[C:8]([CH2:11][N:12]([CH3:14])[CH3:13])[S:9][CH:10]=1.CS[C:17](=[N:20][S:21]([CH3:24])(=[O:23])=[O:22])SC.[CH3:25][NH2:26]>C(O)C>[CH3:13][N:12]([CH2:11][C:8]1[S:9][CH:10]=[C:6]([CH2:5][S:4][CH2:3][CH2:2][NH:1][C:17]([NH:26][CH3:25])=[N:20][S:21]([CH3:24])(=[O:23])=[O:22])[CH:7]=1)[CH3:14]

参加物

5

反応物 3

HCID 6329MethylamineHCID 129265012-[(5-Dimethylaminomethyl-3-thienyl)methylthio]ethylamineHCID 13449843N-[bis(methylsulfanyl)methylidene]methanesulfonamide

生成物 1

HCID 178485212N-[[[2-[[5-(Dimethylaminomethyl)-3-thienylmethyl]thio]ethyl]amino](methylamino)methylene]methanesulphonamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

反応条件

温度
60 °C

実験手順

A mixture of 4-[[2-(amino)ethyl]thio]methyl-N,N-dimethyl-2-thiophenemethanamine (0.4 g) and S,S'-dimethyl-N- (methylsulphonyl)-dithio-carbonimidic acid (0.35 g) in ethanol (10 ml) was heated at 60° C. for 1 hour. A 33% solution of methylamine in ethanol (10 ml) was added and the mixture was stirred for 20 h. The solvent was evaporated in vacuo and the residue was purified by column chromatography on silica using methanol to give the title compound (0.5 g) as an amber gum.

後処理

  1. customThe solvent was evaporated in vacuo
  2. customthe residue was purified by column chromatography on silica

出典と根拠

ORDレコード
ord-97646e3e2fd1497fba083247533837ea
出典データセット
uspto-grants-1983_05
特許番号
US04382929

反応ノート

読み込み中…