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Benzimidazole → 2-(2-(1-(tert-butoxycarbonyl)piperidin-4-yloxy)phenyl)-1H-benzo[d]imidazole-4-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzimidazole | HCID 5798 | — |
| 反応物 | 2,3-Diaminobenzoic acid | HCID 198069 | — |
| 反応物 | Tert-butyl 4-(2-formylphenoxy)piperidine-1-carboxylate | HCID 58279027 | — |
| 生成物 | 2-(2-(1-(tert-butoxycarbonyl)piperidin-4-yloxy)phenyl)-1H-benzo[d]imidazole-4-carboxylic acid | HCID 67203282 | — |
反応手順
The same general procedure outlined above for the preparation of benzimidazole derivatives was used, employing 2,3-diaminobenzoic acid 1 and tert-butyl 4-(2-formylphenoxy)piperidine-1-carboxylate 26 to produce 2-(2-(1-(tert-butoxycarbonyl)piperidin-4-yloxy)phenyl)-1H-benzo[d]imidazole-4-carboxylic acid 27. MS (ESI) calcd for C24H27N3O5: 437.20; found: 438 [M+H].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846947B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-eca130390ed14a34a525b6f814aea8f2 |
| 出典メモ | uspto-grants-2014_09 |