4-Chlorophenol → 1-(4-Chlorophenoxy)-3,3-dimethyl-4-fluoro-2-butanone

HRID 851126ノート

反応式

HRID 851126 の反応式
Br[CH2:2][C:3](=[O:9])[C:4]([CH3:8])([CH3:7])[CH2:5][F:6].[Cl:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Cl:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:2][C:3](=[O:9])[C:4]([CH3:8])([CH3:7])[CH2:5][F:6])=[CH:13][CH:12]=1

参加物

5

反応物 3

HCID 46844-ChlorophenolHCID 11430Potassium CarbonateHCID 130194421-Bromo-3,3-dimethyl-4-fluoro-2-butanone

生成物 1

HCID 221632321-(4-Chlorophenoxy)-3,3-dimethyl-4-fluoro-2-butanone収率 90.5%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
20 °C

実験手順

157 g (0.79 mol) of 1-bromo-3,3-dimethyl-4-fluoro-butan-2-one were added dropwise to a stirred mixture of 102 g (0.79 mol) of p-chlorophenol and 110 g (0.79 mol) of powdered potassium carbonate in 500 ml of acetone at 20° to 30° C., whilst cooling. The mixture was subsequently stirred at 20° C. for 2 hours, the inorganic salt was filtered off and the filtrate was concentrated. The residue was distilled under a high vacuum. 175 g (90% of theory) of 1-(4-chlorophenoxy)-3,3-dimethyl-4-fluoro-butan-2-one of boiling point 112°-119° C./0.05 mm Hg were obtained. ##STR25##

後処理

  1. temperaturewhilst cooling
  2. filtrationthe inorganic salt was filtered off
  3. concentrationthe filtrate was concentrated
  4. distillationThe residue was distilled under a high vacuum

出典と根拠

ORDレコード
ord-35f5b209a34a4e9faaef65f7fa435db1
出典データセット
uspto-grants-1983_05
特許番号
US04382944

反応ノート

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