Chloroacetone → HCID 13136935、化合物

HRID 851202ノート

反応式

HRID 851202 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]2[C:8]3[CH2:13][CH2:12][NH:11][CH2:10][C:9]=3[C:14](=[O:16])[O:15][C:4]=2[CH:3]=1.C(N(CC)CC)C.Cl[CH2:25][C:26](=[O:28])[CH3:27]>C(O)C>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]2[C:8]3[CH2:13][CH2:12][N:11]([CH2:25][C:26](=[O:28])[CH3:27])[CH2:10][C:9]=3[C:14](=[O:16])[O:15][C:4]=2[CH:3]=1

参加物

5

反応物 3

HCID 6571ChloroacetoneHCID 8471TriethylamineHCID 106087088-Methyl-1,2,3,4-tetrahydro-chromeno[3,4-c]pyridin-5-one

生成物 1

HCID 13136935HCID 13136935、化合物収率 77.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 1,2,3,4-tetrahydro-8-methyl-5H-[1]benzopyrano[3,4-c]pyridin-5-one (2.0 g, 0.009 moles), triethylamine (1.4 ml, 0.010 moles), and 1-chloro-2-propanone (0.8 g, 0.009 moles) in ethanol (50 ml) is stirred and heated to reflux. After 20 hours the mixture is cooled and the precipitate filtered off, rinsed with ethanol, and dried to give the product (1.9 g), mp 128°-129° C.

後処理

  1. temperatureheated to reflux
  2. temperatureAfter 20 hours the mixture is cooled
  3. filtrationthe precipitate filtered off
  4. washrinsed with ethanol
  5. customdried

出典と根拠

ORDレコード
ord-82ed3702c3be401f94e157ca06656e99
出典データセット
uspto-grants-1983_05
特許番号
US04382939

反応ノート

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