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Benzimidazole → 2-(2-(difluoromethyl)-4-fluorophenyl)-1H-benzo[d]imidazole-4-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzimidazole | HCID 5798 | — |
| 反応物 | 2,3-Diaminobenzoic acid | HCID 198069 | — |
| 反応物 | 2-(Difluoromethyl)-4-fluorobenzaldehyde | HCID 86652255 | — |
| 生成物 | 2-(2-(difluoromethyl)-4-fluorophenyl)-1H-benzo[d]imidazole-4-carboxylic acid | HCID 67203026 | — |
反応手順
The same general procedure outlined above for the preparation of benzimidazole was used employing 2-(difluoromethyl)-4-fluorobenzaldehyde 45 and 2,3-diaminobenzoic acid 1 as the starting materials to afford 2-(2-(difluoromethyl)-4-fluorophenyl)-1H-benzo[d]imidazole-4-carboxylic acid 46. MS (ESI) calcd for C15H9F3N2O2: 306.6; found: 307 [M+H].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846947B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-74fc318cc7de48ce92ab8b4c2f194d8e |
| 出典メモ | uspto-grants-2014_09 |