Benzimidazole → 2-(2-(difluoromethyl)-4-fluorophenyl)-1H-benzo[d]imidazole-4-carboxylic acid

HRID 85124

反応式

HRID 85124 の反応式
N1C2C=CC=CC=2NC=1.[F:10][CH:11]([F:21])[C:12]1[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:13]=1[CH:14]=O.[NH2:22][C:23]1[C:31]([NH2:32])=[CH:30][CH:29]=[CH:28][C:24]=1[C:25]([OH:27])=[O:26]>>[F:10][CH:11]([F:21])[C:12]1[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:13]=1[C:14]1[NH:32][C:31]2[CH:30]=[CH:29][CH:28]=[C:24]([C:25]([OH:27])=[O:26])[C:23]=2[N:22]=1

参加物

4

反応物 3

HCID 5798BenzimidazoleHCID 1980692,3-Diaminobenzoic acidHCID 866522552-(Difluoromethyl)-4-fluorobenzaldehyde

生成物 1

HCID 672030262-(2-(difluoromethyl)-4-fluorophenyl)-1H-benzo[d]imidazole-4-carboxylic acid

実験手順

The same general procedure outlined above for the preparation of benzimidazole was used employing 2-(difluoromethyl)-4-fluorobenzaldehyde 45 and 2,3-diaminobenzoic acid 1 as the starting materials to afford 2-(2-(difluoromethyl)-4-fluorophenyl)-1H-benzo[d]imidazole-4-carboxylic acid 46. MS (ESI) calcd for C15H9F3N2O2: 306.6; found: 307 [M+H].

出典と根拠

ORDレコード
ord-74fc318cc7de48ce92ab8b4c2f194d8e
出典データセット
uspto-grants-2014_09
特許番号
US08846947B2

関連ノート

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