Benzotrichloride → Propanoyl chloride, 3-bromo-2,2,3,3-tetrafluoro-

反応式

[Br:1][C:2]([F:10])([F:9])[C:3]([F:8])([F:7])[C:4](O)=[O:5].C1(C(Cl)(Cl)[Cl:18])C=CC=CC=1>>[Br:1][C:2]([F:10])([F:9])[C:3]([F:8])([F:7])[C:4]([Cl:18])=[O:5]

参加物

反応物 2

HCID 7367Benzotrichloride

HCID 133289113-Bromo-2,2,3,3-tetrafluoropropanoic acid

生成物 1

HCID 10490449Propanoyl chloride, 3-bromo-2,2,3,3-tetrafluoro-収率 71%

実験手順

A mixture of 375.9 g (1.67 mol) of 3-bromotetrafluoropropionic acid, 10 g of ferric chloride, and 488.7 g (2.50 mol) of benzotrichloride was refluxed for 1.5 h, then crude product was removed, bp about 60°. Redistillation gave 287.9 g (71%) of 3-bromotetrafluoropropionyl chloride, bp 67°-68°. IR (CCl4): 5.53 (C=O). ##STR44##

後処理

temperaturewas refluxed for 1.5 h
customcrude product was removed
distillationRedistillation

出典と根拠

ORDレコード: ord-ba4a6b596f3340188c2cbfdbfd52bfa3
出典データセット: uspto-grants-1983_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04384128

反応ノート

読み込み中…

参加物