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3-(Trifluoromethyl)phenylglyoxal → N-(2-(4-Carbomethoxyphenyl)-1,1-dimethylethyl)-2-hydroxy-2-(3-trifluoromethylphenyl) ethanamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(Trifluoromethyl)phenylglyoxal | HCID 2783284 | — |
| 反応物 | Methyl 4-(2-amino-2-methylpropyl)benzoate | HCID 20134200 | — |
| 生成物 | N-(2-(4-Carbomethoxyphenyl)-1,1-dimethylethyl)-2-hydroxy-2-(3-trifluoromethylphenyl) ethanamine | HCID 20501355 | — |
反応手順
The title compound was prepared as in Example 1a from 3-trifluoromethylphenyl glyoxal (2.0 g) and 2-(4-carbomethoxyphenyl)-1,1-dimethyl ethanamine (2.0 g) and crystallised from hexane m.p. 88°-90°. τ(CDCl3) 8.93 (6H,s), 6.8-8.0 (4H,m+2H replaceable by D2O), 6.1 (3H,s), 5.33 (1H,m), 2.8 (2H,d,J=8 Hz), 2.2-2.6 (4H,m), 2.03 (2H,d,J=8 Hz).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04385066 |
| 出典データセット | uspto-grants-1983_05 |
| ORD ID | ord-52b1dc0c52304037a7afecf74c38009d |
| 出典メモ | uspto-grants-1983_05 |