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Sulfuric Acid → Dimedone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | 3,3-Dimethyl-5-oxohexanoic acid | HCID 11332610 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | Dimedone | HCID 31358 | 82.3% |
反応手順
A solution of 5 parts of 5-keto-3,3-dimethylhexanoic acid and about 15 parts of 73% sulfuric acid was heated for one hour in a 130°-135° oil bath. The cooled solution was then poured into a separatory funnel containing ice and chloroform. The aqueous phase was then washed three times with additional chloroform. The combined organic extractions were then dried and evaporated. There was obtained an 82.3% yield of dimedone. It was further recrystallized from toluene.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04386222 |
| 出典データセット | uspto-grants-1983_05 |
| ORD ID | ord-d7eca5d1c32145dd995fe32b68df792d |
| 出典メモ | uspto-grants-1983_05 |