関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrogen Peroxide | HCID 784 | — |
| 反応物 | 3-Methyl-2-cyclohexen-1-one | HCID 14511 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Ozone | HCID 24823 | — |
| 触媒 | Trioctylmethylammonium chloride | HCID 21218 | — |
| 生成物 | 4-Acetylbutyric acid | HCID 18407 | 48% |
反応手順
Ozone was passed through a solution of 2.0 gms of 3-methyl-2-cyclohexenone at -78° C. for 30 minutes. The mixture was warmed to -20° C. and treated with a solution of 3.0 g of 30% hydrogen peroxide in 3.0 g of 50% NaOH. A drop of Adogen 464 was added and the two phase mixture was stirred vigorously for 1 hour. The aqueous phase was separated and acidified then extracted with ether. Removal of the ether afforded 1.12 g (48%) of 5-keto-hexanoic acid. The identity of the acid was confirmed by comparing the IR spectra of its methyl ester to the known spectra of the same compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04386222 |
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| 出典データセット | uspto-grants-1983_05 |
|---|
| ORD ID | ord-2242d1fd0dcc4c9b94a4b71fbb64ce2e |
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| 出典メモ | uspto-grants-1983_05 |
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