Dimethyl Sulfoxide → HCID 54150769、化合物

HRID 851809ノート

反応式

HRID 851809 の反応式
C[O-].[Na+].CO.C1(S([CH2:15][CH2:16][CH2:17][CH:18]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][C:19]2=O)(=O)=O)C=CC=CC=1.CS(C)=O>C1(C)C=CC=CC=1>[C:18]12[CH2:17][CH2:16][CH:15]=[C:19]1[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH:29]=2

参加物

6

反応物 4

HCID 679Dimethyl SulfoxideHCID 887MethanolHCID 10942334Sodium MethoxideHCID 205012032-[3-(Benzenesulfonyl)propyl]cyclododecan-1-one

生成物 1

HCID 54150769HCID 54150769、化合物収率 76%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

2.37 ml of a 30% solution of sodium methoxide in methyl alcohol (10.2 mmole) were added dropwise to a solution of 0.728 g (2.0 mmole) of 2-(3-phenylsulfonyl-prop-1-yl)-cyclododecanone in 10 ml of toluene as indicated sub letter (b). After 90 min. of heating, 0.57 ml (8.0 mmole) of dimethylsulfoxide (DMSO) were added to the reaction mixture which was then heated to reflux for 4 further hours. After extraction and distillation, there were isolated 0.310 g (76% yield) of the desired compound.

後処理

  1. temperatureAfter 90 min. of heating
  2. temperaturewas then heated
  3. temperatureto reflux for 4 further hours
  4. extractionAfter extraction and distillation

出典と根拠

ORDレコード
ord-4d778dacf7734d94b67b18c12140ad03
出典データセット
uspto-grants-1983_05
特許番号
US04386220

反応ノート

読み込み中…