Dimethyl Sulfoxide → HCID 54150769、化合物

HRID 851810ノート

反応式

HRID 851810 の反応式
C1(S([CH2:10][CH2:11][CH2:12][CH:13]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][C:14]2=O)(=O)=O)C=CC=CC=1.[OH-].[K+].CS(C)=O>C1(C)C=CC=CC=1>[C:13]12[CH2:12][CH2:11][CH:10]=[C:14]1[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH:24]=2

参加物

5

反応物 3

HCID 679Dimethyl SulfoxideHCID 14797Potassium HydroxideHCID 205012032-[3-(Benzenesulfonyl)propyl]cyclododecan-1-one

生成物 1

HCID 54150769HCID 54150769、化合物収率 87%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

10.92 g (0.03 mole) of 2-(3-phenylsulfonyl-prop-1-yl)-cyclododecanone and 11.0 g (0.197 mole) of freshly powdered KOH in 40 ml of toluene were heated to reflux for 30 min. as indicated sub letter (b). After addition of 6 ml (0.085 mole) of DMSO, the reaction mixture was heated to reflux for 12 further hours, then cooled, extracted and finally distilled as indicated hereinabove to afford 5.32 g (87% yield) of the desired compound.

後処理

  1. temperaturethe reaction mixture was heated
  2. temperatureto reflux for 12 further hours
  3. temperaturecooled
  4. extractionextracted
  5. distillationfinally distilled

出典と根拠

ORDレコード
ord-65a0dc51fbae409c8f02de375a63e6c5
出典データセット
uspto-grants-1983_05
特許番号
US04386220

反応ノート

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