Quinoline → 5-Decenoic acid

HRID 851837

反応式

HRID 851837 の反応式
Br[CH:2]([CH2:11][CH2:12][CH2:13][CH3:14])[CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:9]C)=[O:8].N1C2C(=CC=CC=2)C=CC=1.C(OC)(=O)CCCC=CCCCC.C(OC)(=O)CCCCC=CCCC.C(O)(=O)CCCCC=CCCC>>[C:7]([OH:9])(=[O:8])[CH2:6][CH2:5][CH2:4][CH:3]=[CH:2][CH2:11][CH2:12][CH2:13][CH3:14]

参加物

6

反応物 5

HCID 7047QuinolineHCID 22931398Methyl 6-bromodecanoateHCID 53401195Dec-6-enoic acidHCID 53854285HCID 53854285、化合物HCID 54534253Methyl 5-decenoate

生成物 1

HCID 534008795-Decenoic acid収率 35%

実験手順

Methyl 6-bromodecanoate (1.2 g) and quinoline (1.2g) were mixed together, and then allowed to react at 240° C. for 5 minutes. After the reaction was completed, the reaction solution was extracted with ether, washed with dilute sulfuric acid, washed with water, dried, evaporated to remove the solvent, and then distilled, thereby giving a mixture of methyl 5-decenoate and methyl 6-decenoate (310 mg). The mixture was hydrolyzed in a coventional manner, thereby giving a mixture (270 mg) of 5-decenoic acid and 6-decenoic acid (1/1).

後処理

  1. customto react at 240° C. for 5 minutes
  2. extractionthe reaction solution was extracted with ether
  3. washwashed with dilute sulfuric acid
  4. washwashed with water
  5. customdried
  6. customevaporated
  7. customto remove the solvent
  8. distillationdistilled
  9. customgiving

出典と根拠

ORDレコード
ord-8dd77bdcdc434d79a2d242b7afbf50d2
出典データセット
uspto-grants-2007_08
特許番号
US07252849B2

関連ノート

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