Water → HCID 12157386、化合物

HRID 851880ノート

反応式

HRID 851880 の反応式
B(Br)(Br)Br.[CH3:5][O:6][C:7]1[CH:21]=[CH:20][C:10]2[N:11]3[CH2:19][CH2:18][CH2:17][C:12]3=[N:13][S:14](=[O:16])(=[O:15])[C:9]=2[CH:8]=1.[OH2:22]>C(Cl)Cl>[O:15]=[S:14]1(=[O:16])[C:9]2[CH:8]=[C:7]([O:6][C:5]3[CH:9]=[C:8]([OH:22])[CH:7]=[CH:21][CH:20]=3)[CH:21]=[CH:20][C:10]=2[N:11]2[CH2:19][CH2:18][CH2:17][C:12]2=[N:13]1

参加物

5

反応物 3

HCID 962WaterHCID 25134Boron tribromideHCID 11253769HCID 11253769、化合物

生成物 1

HCID 12157386HCID 12157386、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A solution of 68.75 mmol of BBr3 in 25 ml of methylene chloride is added dropwise to a solution, cooled to 0° C., of 27.50 mmol of 7-methoxy-2,3-dihydro-1H-pyrrolo-[2,1-c][1,2,4]benzothiadiazine 5,5-dioxide in 350 ml of methylene chloride. Stirring is carried out at ambient temperature for 24 hours. The reaction mixture is poured into a mixture of ice and water, and the suspension is stirred for 30 minutes. The precipitate is filtered off, rinsed several times with water, filtered under suction and dried in vacuo to yield the expected product.

後処理

  1. stirringthe suspension is stirred for 30 minutes
  2. filtrationThe precipitate is filtered off
  3. washrinsed several times with water
  4. filtrationfiltered under suction
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-c1eaf65283c048ba94d3cea6f186348b
出典データセット
uspto-grants-2007_08
特許番号
US07253163B2

反応ノート

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