Potassium Carbonate → 7-[3-(3-Furyl)phenoxy]-2,3-dihydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine 5,5-dioxide

HRID 851888ノート

反応式

HRID 851888 の反応式
Br[C:2]1[CH:3]=[C:4]([CH:21]=[CH:22][CH:23]=1)[O:5][C:6]1[CH:20]=[CH:19][C:9]2[N:10]3[CH2:18][CH2:17][CH2:16][C:11]3=[N:12][S:13](=[O:15])(=[O:14])[C:8]=2[CH:7]=1.[O:24]1[CH:28]=[CH:27][C:26](B(O)O)=[CH:25]1.C([O-])([O-])=O.[K+].[K+]>C(O)C.O>[O:24]1[CH:28]=[CH:27][C:26]([C:2]2[CH:3]=[C:4]([CH:21]=[CH:22][CH:23]=2)[O:5][C:6]2[CH:20]=[CH:19][C:9]3[N:10]4[CH2:18][CH2:17][CH2:16][C:11]4=[N:12][S:13](=[O:15])(=[O:14])[C:8]=3[CH:7]=2)=[CH:25]1

参加物

6

反応物 3

HCID 11430Potassium CarbonateHCID 2734358Furan-3-boronic acidHCID 694145897-(3-bromophenoxy)-2,3-dihydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine 5,5-dioxide

生成物 1

HCID 694177477-[3-(3-Furyl)phenoxy]-2,3-dihydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine 5,5-dioxide

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

A suspension of the product obtained in Step A of Example 16 (300 mg, 0.76 mmol), 111 mg (0.99 mmol) of 3-furanboronic acid, 137 mg (0.99 mmol) of K2CO3 and 45 mg (0.038 mmol) of tetrakistriphenylphosphine in a mixture of 6 ml of ethanol and 1.8 ml of water is heated at 80° C. for 3 hours under N2. The ethanol is evaporated off in vacuo and the residue is taken up in water and 1N HCl. The precipitate is filtered off to yield the title product.

後処理

  1. customThe ethanol is evaporated off in vacuo
  2. filtrationThe precipitate is filtered off

出典と根拠

ORDレコード
ord-4bd4b7dab0a24d1ab48e3534a80dc8af
出典データセット
uspto-grants-2007_08
特許番号
US07253163B2

反応ノート

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