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Benzene, 1-fluoro-2-methyl-4-nitro- → 3-({[tert-Butyl(diphenyl)silyl]oxy}methyl)-1-(2-methyl-4-nitrophenyl)pyridin-2(1H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzene, 1-fluoro-2-methyl-4-nitro- | HCID 68001 | — |
| 反応物 | 3-({[tert-Butyl(diphenyl)silyl]oxy}methyl)pyridin-2(1H)-one | HCID 59410156 | — |
| 生成物 | 3-({[tert-Butyl(diphenyl)silyl]oxy}methyl)-1-(2-methyl-4-nitrophenyl)pyridin-2(1H)-one | HCID 59410212 | — |
反応手順
Analogously to Example 4A, 1.50 g (4.13 mmol) of the compound from Example 3A are reacted with 704 mg (4.54 mmol) of 2-fluoro-5-nitrotoluene. This gives 570 mg (28% of theory) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846934B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-0bcd3dacdb0645a89ab81d6c03ce4396 |
| 出典メモ | uspto-grants-2014_09 |