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1-(2-Pyridyl)piperazine → (S)-1-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-phenoxy]-3-(4-pyridin-2-yl-piperazin-1-yl)-propan-2-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(2-Pyridyl)piperazine | HCID 94459 | — |
| 反応物 | (S)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole | HCID 11254641 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | (S)-1-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-phenoxy]-3-(4-pyridin-2-yl-piperazin-1-yl)-propan-2-ol | HCID 9889862 | — |
反応手順
The title compound is prepared from a mixture of (S)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole in dimethylformamide and 1-pyridin-2-yl-piperazine in ethanol essentially as described above in Example 21. Purity by LC/MS=100%, [M+H]+=449.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07253165B2 |
| 出典データセット | uspto-grants-2007_08 |
| ORD ID | ord-e0b5f99b17de45018826505a93f31401 |
| 出典メモ | uspto-grants-2007_08 |