化工社化工社 化学情報印刷レポート · 研究参考用
Dimethylformamide → (S)-1-(cyclohexyl-methyl-amino)-3-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-phenoxy]-propan-2-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | (S)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole | HCID 11254641 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | N-Methylcyclohexylamine | HCID 7514 | — |
| 生成物 | (S)-1-(cyclohexyl-methyl-amino)-3-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-phenoxy]-propan-2-ol | HCID 9865612 | — |
反応手順
The title compound is prepared from a mixture of (S)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole in dimethylformamide and N-methylcyclohexylamine in ethanol essentially as described above in Example 21. Purity by LC/MS=100%, [M+H]+=399.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07253165B2 |
| 出典データセット | uspto-grants-2007_08 |
| ORD ID | ord-5a1efa3e0899489a80c9e223a57a8c87 |
| 出典メモ | uspto-grants-2007_08 |