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Potassium Iodide → 2-[3-(2-Methyl-2-nitropropyl)imidazo[1,2-a]pyridin-7-yloxy]-acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | Chloroacetamide | HCID 6580 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | HCID 178441236 | HCID 178441236 | — |
| 溶媒 | Methyl Ethyl Ketone | HCID 6569 | — |
| 生成物 | 2-[3-(2-Methyl-2-nitropropyl)imidazo[1,2-a]pyridin-7-yloxy]-acetamide | HCID 22038569 | 34.3% |
反応手順
3-(2-Methyl-2-nitropropyl)imidazo[1,2-a]pyridin-7-ol (1.5 g, 6.38 mmol), chloroacetamide (1.19 g, 12.73 mmol), potassium carbonate (6.4 mmol) and a small amount of potassium iodide in 2-butanone (30 ml) is heated at reflux overnight. The solids are removed by filtration and the filtrate is concentrated under reduced pressure. The residue is chromatographed on silica gel with dichloromethane/methanol 3:1 to 1:1 to give 640 mg of 2-[3-(2-methyl-2-nitropropyl)imidazo[1,2-a]pyridin-7-yloxy]-acetamide (34%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07253181B2 |
| 出典データセット | uspto-grants-2007_08 |
| ORD ID | ord-5c849ac6426645c392d44416bed12283 |
| 出典メモ | uspto-grants-2007_08 |