2-Amino-4-methylpyridine → 7-Methyl-3-(2-methyl-2-nitropropyl)imidazo[1,2-a]pyridine

反応式

[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1.Br[CH:10]([CH2:13][C:14]([CH3:19])([N+:16]([O-:18])=[O:17])[CH3:15])[CH:11]=O>>[CH3:8][C:6]1[CH:5]=[CH:4][N:3]2[C:10]([CH2:13][C:14]([CH3:19])([N+:16]([O-:18])=[O:17])[CH3:15])=[CH:11][N:1]=[C:2]2[CH:7]=1

参加物

反応物 2

HCID 15332-Amino-4-methylpyridine

HCID 220385582-Bromo-4-methyl4-nitropentanal

生成物 1

HCID 220385657-Methyl-3-(2-methyl-2-nitropropyl)imidazo[1,2-a]pyridine収率 63.4%

実験手順

2-Amino-4-methylpyridine (2.2 g, 20.3 mmol) and 2-bromo-4-methyl-4-nitropentanal (20.3 mmol) are reacted as described in Amine 7 to give 3.0 g of 7-methyl-3-(2-methyl-2-nitropropyl)imidazo[1,2-a]pyridine (63%).

出典と根拠

ORDレコード: ord-88eea8cdc27a44899ea206571ec92fda
出典データセット: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07253181B2

反応ノート

読み込み中…