2-Nitrobenzenesulfonyl chloride → tert-Butyl 4-((2-aminophenyl)sulfonyl)piperazine-1-carboxylate

反応式

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[N+:14]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[S:23](Cl)(=[O:25])=[O:24])([O-])=O>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([S:23]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=2[NH2:14])(=[O:25])=[O:24])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

参加物

反応物 2

HCID 155402-Nitrobenzenesulfonyl chloride

HCID 143452tert-Butyl piperazine-1-carboxylate

生成物 1

HCID 56777210tert-Butyl 4-((2-aminophenyl)sulfonyl)piperazine-1-carboxylate収率 82%

実験手順

The title compound (2 g, 82%) was obtained as a white solid from piperazine-1-carboxylic acid tert-butyl ester and 2-nitrobenzenesulfonyl chloride following the same procedure as described in Preparation 2.

出典と根拠

ORDレコード: ord-1d890801988349caa14b28919fd9ec53
出典データセット: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07253171B2

反応ノート

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