3-Aminopyridine → 2-(2-pyridin-3-yl-2H-tetrazol-5-yl)pyridine

反応式

ClC1[CH:3]=[C:4]([N:8]2[N:12]=[N:11][C:10]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=3)=[N:9]2)[CH:5]=[CH:6][CH:7]=1.[NH2:19]C1C=NC=CC=1.C1C=C(C=O)N=CC=1>>[N:19]1[CH:7]=[CH:6][CH:5]=[C:4]([N:8]2[N:12]=[N:11][C:10]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=3)=[N:9]2)[CH:3]=1

参加物

反応物 3

HCID 100093-Aminopyridine

HCID 142732-Pyridinecarboxaldehyde

HCID 99213692-[2-(3-chlorophenyl)-2H-tetrazol-5-yl]pyridine

生成物 1

HCID 98778862-(2-pyridin-3-yl-2H-tetrazol-5-yl)pyridine

実験手順

Following the procedure described in EXAMPLE 1 for the synthesis of 2-[2-(3-chlorophenyl)-2H-tetrazol-5-yl]pyridine, but using 3-amino pyridine (565 mg, 6.0 mmol) and 2-pyridyl carboxaldehyde (642 mg, 6.0 mmol), 2-(2-pyridin-3-yl-2H-tetrazol-5-yl)pyridine was obtained as an off white solid.

出典と根拠

ORDレコード: ord-70fe5c54221e4415978cf6be25b46623
出典データセット: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07253190B2

反応ノート

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