化工社化工社 化学情報印刷レポート · 研究参考用
Water → HCID 25151661、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Acetaldehyde ammonia | HCID 522583 | — |
| 反応物 | N-{[(5S)-3-{4-[3-(Bromomethyl)-2-oxopyridin-1(2H)-yl]-3-methylphenyl}-2-oxo-1,3-oxazolidin-5-yl]methyl}-5-chlorothiophene-2-carboxamide | HCID 59410175 | — |
| 生成物 | HCID 25151661 | HCID 25151661 | — |
反応手順
At −10° C., 38 mg (0.63 mmol) of aminoethanol are added to a solution of 56 mg (0.11 mmol) of the compound from Example 11A in 1 ml of DMF. After 30 min at −10° C., the mixture is added to water and then extracted three times with ethyl acetate. The organic phases are combined and then freed from the solvent under reduced pressure. The product is purified by preparative HPLC using an acetonitrile/water mixture. This gives 14.5 mg (26% of theory) of the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846934B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-e5c41719a1074ce286fce892844580d6 |
| 出典メモ | uspto-grants-2014_09 |