Methanesulfonyl chloride → Methanesulfonic acid 1-[3-(4-trifluoromethoxy-phenyl)-prop-2-ynyl]-cyclobutylmethyl ester

反応式

[F:1][C:2]([F:20])([F:19])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]#[C:11][CH2:12][C:13]2([CH2:17][OH:18])[CH2:16][CH2:15][CH2:14]2)=[CH:6][CH:5]=1.[CH3:21][S:22](Cl)(=[O:24])=[O:23]>>[F:1][C:2]([F:19])([F:20])[O:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]#[C:11][CH2:12][C:13]2([CH2:17][O:18][S:22]([CH3:21])(=[O:24])=[O:23])[CH2:14][CH2:15][CH2:16]2)=[CH:8][CH:9]=1

参加物

反応物 2

HCID 31297Methanesulfonyl chloride

HCID 69458280{1-[3-(4-Trifluoromethoxy-phenyl)-prop-2-ynyl]-cyclobutyl}-methanol

生成物 1

HCID 86602545Methanesulfonic acid 1-[3-(4-trifluoromethoxy-phenyl)-prop-2-ynyl]-cyclobutylmethyl ester

実験手順

In analogy to the procedure described in example 1G], {1-[3-(4-trifluoromethoxy-phenyl)-prop-2-ynyl]-cyclobutyl}-methanol and methanesulfonyl chloride gave the title compound as yellow oil.

出典と根拠

ORDレコード: ord-c4443b14174d460e8165823911fbba34
出典データセット: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07253192B2

反応ノート

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