Dicyclohexylammonium (RS)-alpha-Methyl-3,5-bis(trifluoromethyl)benzeneacetate → 2-(3,5-Bis(trifluoromethyl)phenyl)propanoic acid
反応式
[CH3:1][CH:2]([C:6]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:9]=[C:8]([C:16]([F:19])([F:18])[F:17])[CH:7]=1)[C:3]([O-:5])=[O:4].C1([NH2+]C2CCCCC2)CCCCC1>C(OCC)(=O)C>[CH3:1][CH:2]([C:6]1[CH:7]=[C:8]([C:16]([F:17])([F:18])[F:19])[CH:9]=[C:10]([C:12]([F:13])([F:14])[F:15])[CH:11]=1)[C:3]([OH:5])=[O:4]参加物
3
実験手順
Dicyclohexylammonium (RS)-α-methyl-3,5-bis(trifluoromethyl)benzeneacetate (Description 4, 31.13 g, 67 mmol) was suspended in ethyl acetate and washed with aqueous citric acid (25%) and water, dried (MgSO4) and the solvent was evaporated under reduced pressure to give the title compound as a colourless solid (19.0 g, 100%). 1H NMR (400 MHz, CDCl3) δ 7.81 (1H, s), 7.78 (2H, s), 3.90 (1H, q, J 7.2 Hz), and 1.60 (3H, d, J 7.2 Hz).