Imidazole → 2-Amino-4-(tert-butyldimethylsilanyloxy)butyric acid

HRID 8529

反応式

HRID 8529 の反応式
N1C=CN=C1.[NH2:6][C@H:7]([C:11]([OH:13])=[O:12])[CH2:8][CH2:9][OH:10].[Si:14](Cl)([C:17]([CH3:20])([CH3:19])[CH3:18])([CH3:16])[CH3:15].O>CN(C=O)C>[NH2:6][CH:7]([CH2:8][CH2:9][O:10][Si:14]([C:17]([CH3:20])([CH3:19])[CH3:18])([CH3:16])[CH3:15])[C:11]([OH:13])=[O:12]

参加物

6

反応物 4

HCID 795ImidazoleHCID 962WaterHCID 12647L-HomoserineHCID 28928tert-Butyldimethylsilyl chloride

生成物 1

HCID 220157142-Amino-4-(tert-butyldimethylsilanyloxy)butyric acid

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Imidazole (20.4 g, 300 mmol) is added to a solution of homoserine (11.9 g, 100 mmol) in DMF (100 mL) and the solution is stirred 15 minutes then cooled to 0° C. tert-Butyldimethylsilyl chloride (13.7 g, 91 mmol) added and the mixture is stirred for ten minutes at 0° C. the for 4 hours at room temperature. The reaction mixture is poured into water (3 L) and the resulting solid is collected by filtration. The isolated product is dried and used without further purification.

後処理

  1. additionadded
  2. stirringthe mixture is stirred for ten minutes at 0° C. the for 4 hours at room temperature
  3. filtrationthe resulting solid is collected by filtration
  4. customThe isolated product is dried
  5. customused without further purification

出典と根拠

ORDレコード
ord-65bf027c2ce34a99952537c84cd0ebc0
出典データセット
uspto-grants-2006_08
特許番号
US07087759B2

関連ノート

読み込み中…