Thiazolidinedione → 4-(2,4-Dioxo-thiazolidin-5-ylidenemethyl)-benzoic acid methyl ester
反応式
[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([CH:10]=O)=[CH:6][CH:5]=1.[S:13]1[CH2:17][C:16](=[O:18])[NH:15][C:14]1=[O:19].N1CCCCC1>COCCO>[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([CH:10]=[C:17]2[S:13][C:14](=[O:19])[NH:15][C:16]2=[O:18])=[CH:6][CH:5]=1参加物
5
実験手順
A solution of 4-formyl-benzoic acid methyl ester (1.0 g, 6.7 mmol), thiazolidine-2,4 dione (0.78 g, 6.7 mmol) and piperidine (0.66 ml, 6.7 mmol) in 2-methoxy-ethanol (20 ml) was refluxed for 2 hrs, cooled to the room temperature and evaporated. The residue was triturated with CH2Cl2 to produce a crystalline material which was collected by filtration to afford the title compound (620 mg, 35% yield). LRMS: 263.3 (calcd.), 264.1 [MH]+ (found).
後処理
- customevaporated
- customThe residue was triturated with CH2Cl2
- customto produce a crystalline material which
- filtrationwas collected by filtration
出典と根拠
- ORDレコード
- ord-b87e1ec306c64217958024a98add380a
- 出典データセット
- uspto-grants-2007_08
- 特許番号
- US07253204B2
反応ノート
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