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Hydrochloric Acid → (+-)-4-Ethyl-4-[(tosyloxy)methyl]-2-oxazolidinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| 反応物 | (+-)-Ethyl-4-(hydroxymethyl)-2-oxazolidinone | HCID 19694098 | — |
| 溶媒 | Sodium chloride; water | HCID 57417360 | — |
| 生成物 | (+-)-4-Ethyl-4-[(tosyloxy)methyl]-2-oxazolidinone | HCID 18968885 | — |
反応手順
Tosyl chloride (142.2 g, Aldrich) was added to an ice-chilled solution of the product from step (a) (102.7 g) dissolved in pyridine (175 ml. Aldrich). The reaction mixture was stirred at ice bath temperature for six hours, then allowed to come to room temperature. The heterogeneous mixture was added to 1500 ml of a solution of brine and 1N HCl, stirred until solids appeared, filtered and washed with diethyl ether to give 194.6 g of a beige solid as the title product. 1H NMR consistent with the proposed structure.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05723458 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-85a305aeebfc4263a0d5dfa4da2ff2f2 |
| 出典メモ | uspto-grants-1998_03 |