Water → 5-[1-Quinolin-6-yl-meth-(z)-ylidene]-2-thioxo-thiazolidin-4-one

HRID 853018ノート

反応式

HRID 853018 の反応式
C(O[C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH:14]=O)[CH:12]=2)[N:7]=[CH:6][CH:5]=1)C.[S:16]1[CH2:22][C:20](=[O:21])[NH:19][C:17]1=[S:18].O>C(O)(=O)C>[N:7]1[C:8]2[C:13](=[CH:12][C:11](/[CH:14]=[C:22]3/[C:20](=[O:21])[NH:19][C:17](=[S:18])[S:16]/3)=[CH:10][CH:9]=2)[CH:4]=[CH:5][CH:6]=1

参加物

5

反応物 3

HCID 962WaterHCID 1201546RhodanineHCID 586153616-Quinolinecarboxaldehyde, 4-ethoxy-

生成物 1

HCID 116662315-[1-Quinolin-6-yl-meth-(z)-ylidene]-2-thioxo-thiazolidin-4-one収率 115.7%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

The suspension of 4-ethoxy-quinoline-6-carbaldehyde (example 3b) (4.0 g, 20 mmol) and rhodanine (2.65 g, 20 mmol) in acetic acid (40 mL) was stirred under reflux for 12 h. After cooling to room temperature, water (50 mL) was added. The solid was collected by filtration, washed with water and dried to obtain 5-[1-quinolin-6-yl-meth-(Z)-ylidene]-2-thioxo-thiazolidin-4-one (6.3 g, 100%) as a brown solid. LC-MS m/e 317 (MH+).

後処理

  1. temperatureunder reflux for 12 h
  2. filtrationThe solid was collected by filtration
  3. washwashed with water
  4. customdried

出典と根拠

ORDレコード
ord-2edf450a61124f1db998ff09ca44f174
出典データセット
uspto-grants-2007_08
特許番号
US07253285B2

反応ノート

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