Hydrochloric Acid → 2-(4-Fluorophenyl)cyclopropane-1-carboxylic acid
反応式
C([O:3][C:4]([CH:6]1[CH2:8][CH:7]1[C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=1)=[O:5])C.O.[Li].CO.Cl>O>[F:15][C:12]1[CH:11]=[CH:10][C:9]([CH:7]2[CH2:8][CH:6]2[C:4]([OH:5])=[O:3])=[CH:14][CH:13]=1参加物
6
反応条件
- 温度
- 80 °C
実験手順
In a round flask was charged with 2-(4-fluoro-phenyl)-cyclopropanecarboxylic acid ethyl ester (1700 mg, 8.16 mmol), lithium monohydrate (1370 mg, 32.7 mmol), methanol (25 mL) and water (10 mL). The mixture was heated at 80° C. for 2 hours. The reaction mixture was rotavaped. The residue was neutralized with 4N hydrochloric acid and extracted with dichloromethane. The dichloromethane layer was washed with brine, dried over sodium sulfate and evaporated to give 1.61 grams of white solid as desired product. LC-MS m/e 179 (MH−).
後処理
- extractionextracted with dichloromethane
- washThe dichloromethane layer was washed with brine
- dry with materialdried over sodium sulfate
- customevaporated
出典と根拠
- ORDレコード
- ord-e241415c28f1486b8f59b99aaf1da2ad
- 出典データセット
- uspto-grants-2007_08
- 特許番号
- US07253285B2
反応ノート
読み込み中…