Hydrochloric Acid → 2-(4-Fluorophenyl)cyclopropan-1-amine

HRID 853027ノート

反応式

HRID 853027 の反応式
C(OC(=O)[NH:7][CH:8]1[CH2:10][CH:9]1[C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1)(C)(C)C.Cl>O1CCOCC1>[F:17][C:14]1[CH:13]=[CH:12][C:11]([CH:9]2[CH2:10][CH:8]2[NH2:7])=[CH:16][CH:15]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 58615363Carbamic acid, (2-(4-fluorophenyl)cyclopropyl)-, 1,1-dimethylethyl ester

生成物 1

HCID 221749042-(4-Fluorophenyl)cyclopropan-1-amine

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

In a round flask was added [2-(4-fluoro-phenyl)-cyclopropyl]-carbamic acid tert-butyl ester (350 mg) and 4N HCl in 1,4-dioxane (3 mL) for 2 hours. The reaction mixture was concentrated by rotavaping to obtain the crude product of 270 mg as white solid. LC-MS m/e 152 (MH+). The crude product was directly used for next step.

後処理

  1. concentrationThe reaction mixture was concentrated

出典と根拠

ORDレコード
ord-e13192096bad49ef9e8e840a3898f1dc
出典データセット
uspto-grants-2007_08
特許番号
US07253285B2

反応ノート

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