6-Bromo-4,4-dimethyl-3,4-dihydronaphthalen-1(2H)-one → 5-bromo-3,3-dimethyl-2,3-dihydro-1H-inden-1-one

HRID 853196ノート

反応式

HRID 853196 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[CH2:7]C[C:5]2([CH3:14])[CH3:13].BrC1C=C2C(CCC2(C)C)=CC=1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[CH2:7][C:5]2([CH3:13])[CH3:14]

参加物

3

反応物 2

HCID 118319356-Bromo-4,4-dimethyl-3,4-dihydronaphthalen-1(2H)-one2 回HCID 124417856-bromo-1,1-dimethyl-2,3-dihydro-1H-indene2 回

生成物 1

HCID 124417825-bromo-3,3-dimethyl-2,3-dihydro-1H-inden-1-one収率 75%

実験手順

Following a procedure similar to that for the preparation of 6-bromo-4,4-dimethyl-3,4-dihydro-2H-naphthalen-1-one (Compound 3) while using 6-bromo-1,1-dimethyl-indan (Compound 11, 2.45 g, 10.9 mmol) as the starting material afforded the title compound (1.95 g, 75% yield) as a white solid:

出典と根拠

ORDレコード
ord-eb8da388bcf74a6e93b72336f3b4e7d0
出典データセット
uspto-grants-2007_08
特許番号
US07253319B2

反応ノート

読み込み中…