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Potassium Carbonate → N-(3-(6,7-dimethoxyquinolin-4-yloxy)propyl)phthalimide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | N-3-Bromopropylphthalimide | HCID 21611 | — |
| 反応物 | DMF dimethylformamide | HCID 17824068 | — |
| 反応物 | HCID 178486804 | HCID 178486804 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | N-(3-(6,7-dimethoxyquinolin-4-yloxy)propyl)phthalimide | HCID 22936492 | 14.4% |
反応手順
6,7-Dimethoxy-4-hydroxyquinoline (4.0 g, 19.5 mM), N-(3-bromopropyl)phthalimide (5.8 g, 21.5 mM), potassium carbonate (5.4 g, 39 mM) and DMF dimethylformamide (20 ml) were stirred at 60° C. for 1.5 hours. Water, ethyl acetate and tetrahydrofuran were added to the reaction solution for extraction. The solid which precipitated after standing for a period was filtered out to obtain N-(3-(6,7-dimethoxyquinolin-4-yloxy)propyl)phthalimide (1.1 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07253286B2 |
| 出典データセット | uspto-grants-2007_08 |
| ORD ID | ord-2cda75dfc51a483b95bc14dd51552ded |
| 出典メモ | uspto-grants-2007_08 |