Acetic Acid → HCID 68008943、化合物

HRID 85328ノート

反応式

HRID 85328 の反応式
[C:1]([OH:4])(=[O:3])[CH3:2].[CH2:5]([O:12][C:13]1[CH:14]=[C:15]([CH2:19][CH2:20][CH2:21][CH2:22][NH:23][CH2:24][CH2:25][CH2:26][CH2:27]O)[CH:16]=[CH:17][CH:18]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>O>[C:1]([O:4][CH2:27][CH2:26][CH2:25][CH2:24][NH:23][CH2:22][CH2:21][CH2:20][CH2:19][C:15]1[CH:16]=[CH:17][CH:18]=[C:13]([O:12][CH2:5][C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:14]=1)(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 176Acetic AcidHCID 680090004-[(3-Benzyloxyphenyl)butylamino]-1-butanol

生成物 1

HCID 68008943HCID 68008943、化合物収率 88%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

To 10 ml of anhydrous acetic acid was added 2.7 g (8.2 mmol) of 4-[(3-benzyloxyphenyl)butylamino]-1-butanol and the mixture was stirred with heating at 80° C. for 1 hour. The reaction mixture was poured into 150 ml of water and subjected to extraction with ethyl acetate. Washing was performed with a saturated sodium bicarbonate solution and then with a saturated saline solution. Drying over anhydrous sodium sulfate and concentration were performed. The residue was purified by silica gel column chromatography to give 2.68 g of a colorless oily matter (yield: 88.0%).

後処理

  1. extractionsubjected to extraction with ethyl acetate
  2. washWashing
  3. dry with materialDrying over anhydrous sodium sulfate and concentration
  4. customThe residue was purified by silica gel column chromatography
  5. customto give 2.68 g of a colorless oily matter (yield: 88.0%)

出典と根拠

ORDレコード
ord-c3dd087daabe4927b0368f1600ef1f5d
出典データセット
uspto-grants-2014_09
特許番号
US08846955B2

反応ノート

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