化工社化工社 化学情報印刷レポート · 研究参考用
Acetic Acid → Ethyl 3-(4-aminophenyl)-2-cyanoacrylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Ethyl cyanoacetate | HCID 7764 | — |
| 反応物 | Diethylamine | HCID 8021 | — |
| 反応物 | 4-Aminobenzaldehyde | HCID 11158 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Ethyl 3-(4-aminophenyl)-2-cyanoacrylate | HCID 3540149 | 83.1% |
反応手順
36 g (0.3 mol) of para-aminobenzaldehyde are suspended in 300 ml of ethanol. 33.9 g (0.3 mol) of ethyl cyanoacetate and a mixture of 0.375 ml of diethylamine and 1.125 ml of acetic acid, as catalyst, are added to the suspension. The reaction mixture is refluxed for 2 hours, left to cool and then crystallized. After separating out the crystals by filtration and drying, 53.9 g (83% yield) of ethyl 3-(4-aminophenyl)-2-cyanoacrylate are obtained in the form of orange-coloured crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07255853B2 |
| 出典データセット | uspto-grants-2007_08 |
| ORD ID | ord-3858f6c5ab584ac1a24c0584ae3779a6 |
| 出典メモ | uspto-grants-2007_08 |