2,2-Dimethylspiro[5,5]undec-8-en-1-one → HCID 22935662、化合物

反応式

[CH3:1][C:2]1([CH3:14])[CH2:7][CH2:6][CH2:5][C:4]2([CH2:12][CH2:11][CH:10]=[CH:9][CH2:8]2)[C:3]1=[O:13].[CH3:15][Li]>>[CH3:15][C:3]1([OH:13])[C:4]2([CH2:12][CH2:11][CH:10]=[CH:9][CH2:8]2)[CH2:5][CH2:6][CH2:7][C:2]1([CH3:14])[CH3:1]

参加物

反応物 2

HCID 103525712,2-Dimethylspiro[5,5]undec-8-en-1-one

HCID 178418348HCID 178418348、化合物

生成物 1

HCID 22935662HCID 22935662、化合物収率 98%

実験手順

2,2-Dimethylspiro[5,5]undec-8-en-1-one was treated with methyllithium according to the general procedure (example 2, procedure 5) to give 1,2,2-trimethylspiro[5,5]undec-8-en-1-ol in 98% yield. The crude product was purified by bulb-to-bulb distillation (B.p.=140-150° C./0.032 mbar).

出典と根拠

ORDレコード: ord-71c0e234b0864c9596773ad487e44cc1
出典データセット: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07256170B2

反応ノート

読み込み中…