Sulfuric Acid → 8-{[(2S)-2-(Methoxymethyl)pyrrolidin-1-yl]sulfonyl}-3,4-dihydropyrimido[1,2-a]indol-10(2H)-one

反応式

[CH3:1][O:2][CH2:3][C@@H:4]1[CH2:8][CH2:7][CH2:6][N:5]1[S:9]([C:12]1[CH:20]=[CH:19][C:18]2[N:17]3[CH2:21][CH2:22][CH2:23][N:24]=[C:16]3[C:15]3(OCCC[O:25]3)[C:14]=2[CH:13]=1)(=[O:11])=[O:10].OS(O)(=O)=O.[NH4+].[OH-]>>[CH3:1][O:2][CH2:3][C@@H:4]1[CH2:8][CH2:7][CH2:6][N:5]1[S:9]([C:12]1[CH:20]=[CH:19][C:18]2[N:17]3[CH2:21][CH2:22][CH2:23][N:24]=[C:16]3[C:15](=[O:25])[C:14]=2[CH:13]=1)(=[O:11])=[O:10]

参加物

反応物 3

HCID 1118Sulfuric Acid

HCID 14923Ammonium Hydroxide

HCID 115462928'-{[(2S)-2-(Methoxymethyl)pyrrolidinyl]sulfonyl}-3',4'-dihydrospiro(1,3-dioxane-2,10' (2'H)-pyrimido(1,2-a)indole)

生成物 1

HCID 115667308-{[(2S)-2-(Methoxymethyl)pyrrolidin-1-yl]sulfonyl}-3,4-dihydropyrimido[1,2-a]indol-10(2H)-one収率 79%

実験手順

8′-{[(2S)-2-(Methoxymethyl)pyrrolidinyl]sulfonyl}-3′,4′-dihydrospiro(1,3-dioxane-2,10′ (2′H)-pyrimido(1,2-a)indole) (1.30 g, 3.32 mmol) was added portion-wise to concentrated H2SO4 (13 mL) over a period of 15 minutes with cooling in an ice bath. The mixture was allowed to warm to room temperature, stirred for 1.25 hours, poured into ice and basified to pH 10.5 by the careful addition of concentrated NH4OH maintaining internal ice with an external ice bath. The resulting bright yellow-orange solid was filtered, dried, and dissolved in CH2Cl2. After stirring for 1 hour the solution was filtered and the solid was dried in vacuo at 52° C. to give the title compound as a bright yellow solid (0.95 g, 79% yield). Anal: Calc'd. for C17H21N3O4S : C, 56.18; H, 5.82; N, 11.56; Found: C, 56.38; H, 5.90; N, 11.43. NMR: consistent. MS: (ES−) m/z 362 [M−H]. IR: consistent. m.p.: 171-172° C. Opt. Rotation: −109.70 (calculated) at 25° C. in CHCl3 (1%concentration), wavelength 589.