Potassium Carbonate → HCID 15546708、化合物

HRID 854250ノート

反応式

HRID 854250 の反応式
[Cl:1][C:2]1[C:3]2[CH:11]=[CH:10][NH:9][C:4]=2[N:5]=[C:6]([CH3:8])[N:7]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:18]([O:20][C:21](=[O:26])[CH2:22][CH2:23][CH2:24]Br)[CH3:19]>CN(C=O)C>[CH2:18]([O:20][C:21](=[O:26])[CH2:22][CH2:23][CH2:24][N:9]1[C:4]2[N:5]=[C:6]([CH3:8])[N:7]=[C:2]([Cl:1])[C:3]=2[CH:11]=[CH:10]1)[CH3:19]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 76300Ethyl 4-bromobutyrateHCID 109208984-CHLORO-2-METHYL-7H-PYRROLO[2,3-D]PYRIMIDINE

生成物 1

HCID 15546708HCID 15546708、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
50 °C

実験手順

0.5 g (3 mmol) of 4-chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine (prepared according to West and Beauchamp, J. Org. Chem. 26 (1961) 3809) was dissolved in 3 ml DMF and 2.06 g (15 mmol) of potassium carbonate was added to this solution. 0.431 ml (3 mmol) of 4-bromobutyric acid ethyl ester was added and the mixture was stirred at 50° C. for 45 minutes. The reaction mixture was diluted with 50 ml EE and washed three times with water, dried over MgSO4, filtered and the solvent was removed in vacuo. Yield: 0.8 g.

後処理

  1. additionThe reaction mixture was diluted with 50 ml EE
  2. washwashed three times with water
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. customthe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-3b046e1d6b994a2b81a9222878e57b4d
出典データセット
uspto-grants-2007_08
特許番号
US07259159B2

反応ノート

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